SUPPLEMENTATION OF GENERAL ANAESTHESIA WITH NARCOTIC ANALGESICS

Supplementation of general anaesthesia with narcotic analgesics.

Four analgesic drugs--fentanyl, phenoperidine, morphine and pethidine--were compared in a double-blind trial involving 113 patients paralysed and ventilated with nitrous oxide and oxygen. The differences between the drugs were relatively small. There were only slight differences in "duration of action", a term which is questioned in this context. Pethidine appeared to have a slightly longer dur...

Hepatotoxicity of non-narcotic analgesics.

The central role of the liver in drug metabolism sets the stage for drug-related hepatotoxicity. The incidence of hepatotoxicity associated with non-narcotic analgesics is low, but their widespread use both prescription and over-the-counter-makes analgesic-associated hepatotoxicity a clinically and economically important problem. Hepatotoxicity is considered a class characteristic of nonsteroid...

Perioperative Effects of Different Narcotic Analgesics Used to Improve Effectiveness of Total Intravenous Anaesthesia.

OBJECTIVE We aimed to evaluate the depth of anaesthesia, perioperative haemodynamics, postoperative pain scores, analgesic consumption in patients receiving remifentanil- or alfentanil-based total intravenous anaesthesia for single-level lumbar discectomy. METHODS Seventy patients undergoing discectomy were enrolled in the study. Patients were intravenously administered an initial bolus dose ...

Narcotic analgesics as adjuncts to dental practice.

Pain is both a symptom and a sensation. As a symptom, pain signals danger and thus provokes appropriate reflexes. Sher­ rington,2 accordingly, described pain as “the psychical adjunct of an imperative protective reflex.” From a therapeutic viewpoint, pain is a valuable clinical symptom to the practitioner. It also follows that the management of pain— a symptom— must be subject to the same limit...

The use of narcotic analgesics in terminal illness.